2012年
Ryo Hanyu R, Wehbi V, Hayata T, Moriya S, Feinstein T, Ezura Y, Nagao M, Saita Y, Hemmi H, Notomi T, Nakamoto T, Schipani E, Takeda S, Kaneko K, Kurosawa H, Karsenty G, Kronenberg H, Vilardaga JP, Noda M. Anabolic action of PTH regulated by the b2-adrenergic receptor. Proceedings of the National Academy of Sciences of the United States of America 109(19):7433-8, 2012
Aryal SAC, Miyai K, Ezura Y, Hayata T, Notomi T, Nakamoto T, Pawson T, Noda M Nck1 deficiency accelerates bone loss in unloading condition. Journal of Cellular Physiology 2013 ( in press)
Suzuki T, Notomi T, Miyajima D, Mizoguchi F, Hayata T, Nakamoto T, Hanyu R, Kamolratanakul P, Mizuno A, Suzuki M, Ezura Y, Izumi Y, Noda M Osteoblastic differentiation enhances expression of TRPV4 that is required for calcium oscillation induced by mechanical force Bone 2013 (in revision)
Notomi T, Ezura Y, Noda M. Identification of two-pore channel 2 as a novel regulator of osteoclastogenesis. Journal of Biological Chemistry 2012 ;287(42):35057-64
Miyajima D, Hayata T, Suzuki T, Hemmi H, Nakamoto T, Notomi T, Amagasa T, B嗾tcher RT, Costell M, F郭sler R, Ezura Y, Noda M. Profilin1 regulates sternum development and endochondral bone formation. Journal of Biological Chemistry 2012 ;287(40):33545-53.
Ono N, Nakashima K, Schipani E, Hayata T, Ezura Y, Soma K, Kronenberg HM, Noda M. Constitutively active pth/pthrp receptor specifically expressed in osteoblasts enhances bone formation induced by bone marrow ablation. Journal of Cellular Physiology; 227(2):408-15, 2012
Izu Y, Ezura Y, Mizoguchi F, Kawamata A, Nakamoto T, Nakashima K, Hayata T, Hemmi H, Bonaldo P, Noda M. Type VI collagen deficiency induces osteopenia with distortion of osteoblastic cell morphology. Tissue and Cell; 44(1):1-6, 2012
Hemmi H, Zaidi N, Wang B, Matos I, Fiorese C, Lubkin A, Zbytnuik L, Suda K, Zhang K, Noda M, Kaisho T, Steinman RM, and Idoyaga J. Treml4, an Ig superfamily member, mediates presentation of several antigens to T cells in vivo, including protective immunity to HER2 protein. The Journal of Immunology; 188(3):1147-55, 2012
Sakuma T, Nakamoto T, Hemmi H, Kitazawa S, Kitazawa R, Notomi T, Hayata T, Ezura Y, Amagasa T, Noda M. CIZ/NMP4 is expressed in B16 melanoma and forms a positive feedback loop with RANKL to promote migration of the melanoma cells. Journal of Cellular Physiology 227(7):2807-12, 2012
2011年
Nagao M, Feinstein T, Ezura Y, Hayata T, Notomi T, Saita Y, Hanyu R, Hemmi H, Izu Y, Takeda S, Wang K, Rittling S, Nakamoto T, Kaneko K, Kurosawa H, Karsenty G, Denhardt DT, Vilardaga JP, Noda M. Sympathetic control of bone mass regulated by osteopontin. Proceedings of the National Academy of Sciences of the United States of America; 108(43):17767-72, 2011
Nagao M, Saita,Y, Hanyu,R, Hemmi H, Notomi T Hayata T, Nakamoto T, Kaneko K, Kurosawa H, Ishii S, Ezura Y, Noda M. Schnurri-2 deficiency counteracts against bone loss induced by ovariectomy. Journal of Cellular Physiology；226：573-578, 2011
Kamolratanakul P, Hayata T, Ezura Y, Kawamata A, Hayashi C, Yamamoto Y, Hemmi H, Nagao M, Hanyu R, Notomi T, Nakamoto T,Amagasa T, Akiyoshi K, Noda M. Nanogel-based scaffold delivery of prostaglandin E(2) receptor-specific agonist in combination with a low dose of growth factor heals critical-size bone defects in mice. Arthritis Rheum; 63(4):1021-33, 2011
Hanyu R, Hayata T, Nagao M, Saita Y, Hemmi H, Notomi T, Nakamoto T, Schipani E, Knonenbery H, Kaneko K, Kurosawa H, Ezura Y, Noda M. Per-1 is a specific clock gene regulated by parathyroid hormone (PTH) signaling in osteoblasts and is functional for the transcriptional events induced by PTH. Journal of Cellular Biochemistry;112：433-438, 2011
Seo S Nakamoto T, Takeshita M, Suzuki T, Ichikawa M, Noda M, Ogawa S, Honda H, Oda H, Kurokawa M. Cas-L regulates myeloid cell motility and suppresses progression of leukemia induced by p210Bcr/Abl. Cancer Science; 102(12):2109-2117, 2011
Morishita M, Ono N, Miyai K, Nakagawa T, Hanyu R, Nagao M, Kamolratanakul P, Notomi T, Rittling SR, Denhardt DT,Kronenberg HM, Ezura Y, Hayata T, Nakamoto T, Noda M. Osteopontin deficiency enhances parathyroid hormone/parathyroid hormone related peptide receptor (PPR) signaling-induced alteration in tooth formation and odontoblastic morphology. Tissue and Cell; 43:196-200, 2011
Kawamata A, Inoue A, Miyajima D, Hemmi H, Mashima R, Hayata T, Ezura Y, Amagasa T, Yamanashi Y, Noda M. Dok-1 and Dok-2 deficiency induces osteopenia via regulation of osteoclasts. Journal of Cellular Physiology; 226(12):3087-93, 2011
Kondo H, Ezura Y, Nakamoto T, Hayata T, Notomi T, Sorimachi H, Takeda S, Noda M. MURF1 deficiency suppresses unloading-induced effects on osteoblasts and osteoclasts to lead to bone loss. Journal of Cellular Biochemistry; 112(12):3525-30, 2011
Yumoto K, Nifuji A, Rittling SR, Tsuchiya Y, Kon S, Uede T, Denhardt DT, Hemmi H, Nakamoto T, Notomi T, Hayata T, Ezura Y, Noda M. Osteopontin Deficiency Suppresses TNF-alpha-Induced Apoptosis in Chondrocytes. Cartilage; in press, 2011
2010年
Mizoguchi F, Izu Y, Hayata T, Hemmi H, Nakashima K, Nakamura T, Kato S, Miyasaka N, Ezura Y, Noda M. Osteoclast-specific Dicer gene deficiency suppresses osteoclastic bone resorption. J Cell Biochem. ;109(5):866-75. 2010
Ampornaramveth Salingcarnboriboon, R., Pavasant, P., Noda, M. Cbl-b Enhances Runx2 Protein Stability and Augments Osteocalcin Promoter Activity in Osteoblastic Cell Lines Journal of Cellular Physiology; 224:743-7, 2010
Shimizu S, Okuda N, Kato N, Rittling SR, Okawa A, Shinomiya K, Muneta T, Denhardt DT, Noda M, Tsuji K, Asou Y. Osteopontin deficiency impairs wear debris-induced osteolysis via regulation of cytokine secretion from murine macrophages. Arthritis Rheum. 62(5):1329-37. 2010
Nifuji A, Ideno H, Ohyama Y, Takanabe R, Araki R, Abe M, Noda M, Shibuya H. Nemo-like kinase (NLK) expression in osteoblastic cells and suppression of osteoblastic differentiation. Exp Cell Res. 15;316(7):1127-36. 2010
2009年
Miyai K, Yoneda M, Hasegawa U, Toida S, Izu Y, Hemmi H, Hayata T, Ezura Y, Mizutani S, Miyazono K, Akiyoshi K, Yamamoto T, Noda M ANA deficiency enhances BMP-induced ectopic bone formation via transcriptional events. Journal of Biological Chemistry; 284:10593-600, 2009
Izu Y, Mizoguchi F, Kawamata A, Hayata T, Nakamoto T, Nakashima K, Inagami T, Ezura Y, Noda M. Angiotensin II type 2 receptor blockade increases bone mass. Journal of Biological Chemistry; 284:4857-64, 2009
Ezura Y, Koga H, Muneta T, Sekiya I, Noda M Methylation status of CpG-islands in the promoter regions of signature genes during chondrogenesis of human synovium-derived mesenchymal stem cells. Arthritis & Rheumatism; 60:1416-1426, 2009
Hayashi C, Hasegawa U, Saita Y, Hemmi H, Hayata T, Nakashima K, Ezura Y, Amagasa T, Akiyoshi K, Noda M Osteoblastic Bone Formation Is Induced by Using Nanogel-Crosslinking Hydrogel as Novel Scaffold for Bone Growth Factor. Journal of Cellular Physiology; 220:1-7,2009
Mizoguchi F, Izu Y, Hayata T, Hemmi H, Nakashima K, Nakamura T, Kato S, Miyasaka N, Ezura Y, Noda M Osteoclast-specific Dicer gene deficiency suppresses osteoclastic bone resorption. Journal of Cellular Biochemistry; 2009 in press
2008年
Ono N., Nakashima K., Rittling S.R., Schipani E., Hayata T., Ezura Y., Soma K., Denhardt D.T., Kronenberg H.M., Noda M. Osteopontin Negatively Regulates parathyroid hormone receptor signaling in osteoblasts Journal of Biological Chemistry 283:19400-19409, 2008
Kawamata A., Izu Y., Yokoyama H., Hayata T., Amagasa T., Wagner E.F., Nakashima K., Ezura Y., Noda M. JunD suppresses bone formation and contributes to low bone mass induced by estrogen depletion. Journal of Cellular Biochemistry. 103:1037-45, 2008
Mizoguchi F., Mizuno A., Hayata T., Nakashima K., Heller S., Ushida T., Sokabe M., Miyasaka N., Suzuki M., Ezura Y., Noda M. Transient Receptor Potential Vanilloid 4 Deficiency Suppresses Unloading-Induced Bone Loss. Journal of Cellular Physiology. 216:47-53, 2008
Hayata T., Nakamoto T., Ezura Y., Noda M. Ciz, a transcription factor with a nucleocytoplasmic shuttling activity, interacts with C-propeptides of type I collagen Biochemical and Biophysical Research Communications. 368:205-10, 2008
Chung C.J., Soma K., Rittling S.R., Denhardt D.T., Hayata T., Nakashima K., Ezura Y., Noda M. OPN deficiency suppresses appearance of odontoclastic cells and resorption of the tooth root induced by experimental force application. Journal of Cellular Physiology 214:614-20, 2008
Washio-Oikawa K., Nakamura T., Usui M., Yoneda M., Ezura Y., Ishikawa I., Nakashima K., Noda T., Yamamoto T., Noda M. Cnot7 Null Mice Exhibit High Bone Mass Phenotype and Modulation of BMP Actions. Journal of Bone Mineral Research 22:1217-23, 2007
Kanda T., Yoshida Y., Izu Y., Nifuji A., Ezura Y., Nakashima K., Noda M. PlexinD1 deficiency induces defects in axial skeletal morphogenesis. Journal of Cellular Biochemistry 101:1329-37,2007
Ishijima M., Tsuji K., Rittling S.R., Yamashita T., Kurosawa H., Denhardt D.T., Nifuji A., Noda M. Osteopontin is required for mechanical stress-dependent signals to bone marrow cells Journal of Endocrinology 193:235-43, 2007
Hino K., Nakamoto T., Nifuji A., Morinobu M., Ezura Y., Yamamoto H., Noda M. Deficiency of CIZ, a nucleocytoplasmic shuttling protein, prevents unloading-induced bone loss through the enhancement of osteoblastic bone formation in vivo. Bone 40 :852-860 2007 Suzuki H., Amizuka N., Oda K., Noda M., Ohshima H., Maeda T., Involvement of the klotho protein in dentin formation and mineralization. Anatomical Record 291:183-190, 2008
Suzuki H., Amizuka N., Oda K., Noda M., Ohshima H., Maeda T. Histological and elemental analyses of impaired bone mineralization in klotho-deficient mice. J Anat. 212:275-85, 2008
Nakamoto T., Seo S., Sakai R., Kato T., Kutsuna H., Kurokawa M., Noda M., Miyasaka N., Kitagawa S. Expression and tyrosine phosphorylation of Crk associated substrate lymphocyte type (Cas-L) protein in human neutrophils. Journal of Cellular Biochemistry;105:121-128, 2008
Ajima R., Akiyama T., Usui M., Yoneda M., Yoshida Y., Nakamura T., Minowa O., Noda M., Tanaka S., Noda T., Yamamoto T. Osteoporotic bone formation in mice lacking tob2; involvement of Tob2 in RANK ligand expression and osteoclasts differentiation. FEBS Lett. 582:1313-8, 2008
Tazaki T, Miyazaki K, Hiyama E, Nakamoto T, Sakai R, Yamasaki N, Honda Z, Noda M, Miyasaka N, Sueda T, Honda H. Functional analysis of Src homology 3-encoding exon (exon 2) of p130Cas in primary fibroblasts derived from exon 2-specific knockout mice. Genes Cells;13:145-57, 2008
Hemmi H, Idoyaga J, Suda K, Suda N, Kennedy K, Noda M, Aderem A, Steinman RM, A new Trem family member, Treml4, binds to dead cells and is a DAP12 linked marker for subsets of mouse macrophages and dendritic cells. Journal of Immunology; 182：1278-86, 2008
2007年
Saita Y., Takagi T., Kitahara K., Usui M., Ezura Y., Nakashima K., Kurosawa H., Ishii S., Noda M. Lack of schnurri-2 expression associates with reduced bone remodeling and osteopenia. Journal of Biological Chemistry 282:12907-15, 2007
Ono N., Nakashima K., Schipani E., Hayata T., Ezura Y., Soma K., Kronenberg H.M., Noda M. Constitutively active parathyroid hormone receptor signaling in cells in osteoblastic lineage suppresses mechanical unloading-induced bone resorption. Journal of Biological Chemistry 282:25509-16, 2007
Kato N., Kitahara K., Rittling S.R., Nakashima K., Denhardt D.T., Kurosawa H., Ezura Y., Noda M. Osteopontin deficiency enhances anabolic action of EP4 agonist at a sub-optimal dose in bone. Journal of Endocrinology. 193:171-82, 2007
Hayashi C., Rittling S., Hayata T., Amagasa T., Denhardt D. T., Ezura Y., Nakashima K., Noda M. Serum osteopontin, an enhancer of tumor metastasis to bone, promotes B16 melanoma cell migration. Journal of Cellular Biochemistry. 101:979-86, 2007
Shimoyama A., Wada M., Ikeda F., Hata K., Matsubara T., Nifuji A., Noda M, Amano K., Yamaguchi A., Nishimura R., Yoneda T. Ihh/Gli2 Signaling Promotes Osteoblast Differentiation by Regulating Runx2 Expression and Function. Molecular Biology of the Cell 18:2411-8, 2007
Kato N., Hasegawa U., Morimoto N., Saita Y., Nakashima K., Ezura Y., Kurosawa H., Akiyoshi K., Noda M. Nanogel-based delivery system enhances PGE(2) effects on bone formation. Journal of Cellular Biochemistry 101:1063-70, 2007
Yamashita T., Yao Z., Li F., Zhang Q., Badell I.R., Schwarz E.M., Takeshita S., Wagner E.F., Noda M., Matsuo K., Xing L., Boyce B.F. NF-kB p50 and p52 regulate RANKL and TNF-induced osteoclast precursor differentiation by activating c-Fos and NFATc1. Journal of Biological Chemistry 282:18245-53, 2007
Okuda N., Takeda S., Shinomiya K., Muneta T., Itoh S., Noda M., Asou Y. ED-71, a novel vitamin D analog, promotes bone formation and angiogenesis and inhibits bone resorption after bone marrow ablation Bone. 40:281-92. 2007
17. Nguyen S.T., Hasegawa S., Tsuda H., Tomioka H., Ushijima M., Noda M., Omura K and Miki Y Identification of a predictive gene expression signature of cervical lymph node metastasis in oral squamous cell carcinoma. Cancer Science 98:740-6, 2007
L史ard V., Brideau G., Blais F., Salingcarnboriboon R., Wagner G., Roehrl M.H., Noda M., Duprez D., Houillier P., Rossert J. Scleraxis and NFATc regulate the expression of the pro-alpha1(I) collagen gene in tendon fibroblasts. Journal of Biological Chemistry 15;282:17665-75, 2007
2006年
Inoue K., Mikuni-Takagaki Y., Oikawa K., Itoh T., Inada M., Noguchi T., Park J.S., Onodera T., Krane S.M., Noda M., Itohara S. A crucial role for matrix metalloproteinase 2 in osteocytic canalicular formation and bone metabolism. Journal of Biological Chemistry, 281:33814-24, 2006
Salingcarnboriboon R., Tsuji K., Komori T., Nakashima K., Ezura Y., Noda M. Runx2 is a Target of Mechanical Unloading to Alter Osteoblastic Activity and Bone Formation in Vivo. Endocrinology 147:2296-305, 2006
Koyama Y., Rittling S.R., Tsuji K., Hino K., Salincarnboriboon R., Yano T., Taketani Y., Nifuji A., Denhardt D.T, Noda M. Osteopontin deficiency suppresses high phosphate load-induced bone loss via specific modulation of osteoclasts. Endocrinology. 147:3040-9, 2006
Suzuki H., Amizuka N., Noda M., Amano O., Maeda T. Histological and immunohistochemical changes in the submandibular gland in klotho-deficient mice. Archives of Histology and Cytology, 69:119-128,2006
Hino K., Nifuji A., Morinobu M., Tsuji K., Ezura Y., Nakashima K., Yamamoto H., Noda M. Unloading-induced bone loss was suppressed in gold-thioglucose treated mice. Journal of Cellular Biochemistry, 99:845-52. 2006
Washio-Oikawa K., Nakamura T., Usui M., Yoneda M., Ezura Y., Ishikawa I., Nakashima K., Yamamoto T., Noda M. Expression Analysis of LacZ gene placed in the locus of Cnot7 exhibits its activity in osteoblasts in vivo and in mineralized nodules in vitro. Journal of Cellular Biochemistry, 99:538-44. 2006
Ishijima M., Ezura Y., Tsuji K., Rittling S.R., Kurosawa K., Denhardt D. T., Emi M., Nifuji A., Noda M. Osteopontin is associated with nuclear factor kB gene expression during tail-suspension-induced bone loss Experimental Cell Research. 312:3075-83. 2006
Harmey D., Johnson K.A., Zelken J., Camacho N.P., Hoylaerts M.F., Noda M., Terkeltaub R, Milln JL Elevated Skeletal Osteopontin Levels Contribute to the Hypophosphatasia Phenotype in Akp2_/_ Mice Journal Of Bone and Mineral Research 21:1377-86. 2006
2005年
Morinobu M., Nakamoto T., Hino K., Tsuji K., Shen Z.J., Nifuji A., Yamamoto H., Hirai H, Noda M. CIZ reduces adult bone mass in vivo via inhibition of BMP-induced bone formation. Journal of Experimental Medicine 201:961-970, 2005
Elefteriou F., Ahn J.D., Takeda S., Starbuck M., Yang X., Liu X., Kondo H., Richards W.G., Bannon T.W., Noda M., Clement K., Vaisse C., Karsenty G. Sympathetic regulation of osteoclastogenesis is required for gonadectomy-induced bone loss and antagonized by CART. Nature 433.7028, 2005
Kondo H., Nifuji A., Takeda S., Ezura Y., Rittling S., Denhardt D.T., Nakashima K., Karsenty G., Noda M. Unloading induces osteoblastic cell suppression and osteoclastic cell activation to lead to bone loss via sympathetic nervous system. Journal of Biological Chemistry 280:30192-200, 2005
Suzuki H., Amizuka N., Oda K., Li M., Yoshie H., Ohshima H., Noda M., Maeda T. Histological Evidences on Altered Distribution of Osteocytes and Bone Matrix Synthesis in Klotho Deficient Mice. Archives of Histology and Cytology l.;68:371-81, 2005